Recent Publications

Ringel, A.E., R. Ryznar, H. Picariello, K-L. Huang, A. G. Lazarus, and S. G. Holmes, 2013. Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase) is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination. PLOS Genetics 9 (10): e1003871.

Sharma, U., D. Stefanova, and S. G. Holmes, 2013. Histone variant H2A.Z regulates sister chromatid cohesion in Saccharomyces cerevisiae. Molecular and Cellular Biology 33: 3473-3481.

Motwani, T., M. Poddar, and S.G. Holmes, 2012. Sir3 and Epigenetic Inheritance of Silent Chromatin in Saccharomyces cerevisiae. Molecular and Cellular Biology 32: 2784-2793.

Lazarus, A.G. and S. G. Holmes, 2011.  A cis-acting tRNA gene imposes the cell cycle progression requirement for establishing silencing at the HMR locus in yeast.  Genetics 187: 425-439.

Martins-Taylor, K., U. Sharma, T. Rozario, and S. G. Holmes, 2011. H2A.Z (Htz1) controls the cell-cycle dependent establishment of transcriptional silencing at yeast telomeres. Genetics 187:89-104.

 Motwani, T., R. Doris, S. G. Holmes, and M. R. Flory, 2010. Ccq1p and the Condensin Proteins Cut3p and Cut14p Prevent Telomere Entanglements in the Fission Yeast Schizosaccharomyces pombe.   Eukaryotic Cell 9:1612-1621.

Hickman, M.,  K. McCullough, A. Woike, L. Raducha-Grace, T. Rozario, M. L. Dula, E. Anderson, D. Margalit, and S. G. Holmes, 2007. Isolation and characterization of conditional alleles of the yeast SIR2 gene.  Journal of Molecular Biology 367:1246-1257.

Matecic, M., K. Martins-Taylor, M. Hickman, J. Tanny, D. Moazed, and S. G. Holmes, 2006.  New alleles of SIR2 define cell cycle specific silencing functions. Genetics 173:1939-1950.

Martins-Taylor, K., M.L. Dula, and S.G. Holmes, 2004. Heterochromatin spreading at yeast telomeres occurs in M-phase. Genetics 168: 65-75.

Papacs, L.A., Y. Sun, E. Anderson, J. Sun, and S. G. Holmes, 2004.  REP3-mediated silencing in Saccharomyces cerevisiaeGenetics 166: 79-87.

Matecic, M., S. Stuart, and S.G. Holmes, 2002.  SIR2-induced inviability is suppressed by histone H4 overexpression.  Genetics 162: 973-976.

Holmes, S.G. and M.M. Smith, 2001. Replication of minichromosomes in Saccharomyces cerevisiae is sensitive to histone gene copy number and strain ploidy.  Yeast. 18: 291-300.;2-V/full

Dula, M.L. and S.G. Holmes, 2000.  Mga2p and Spt23p are modifiers of transcriptional silencing in yeast.  Genetics 156: 933-941.

MCB_cover_sharma et al

Assay for chromosome cohesion from Sharma et al, Molecular and Cellular Biology 33: 3473-3481