Recent Publications
Rogers, A.M., N.R. Neri, L. Chigweshe, and S.G. Holmes, 2024. Histone variant H2A.Z and linker histone H1 influence chromosome condensation in Saccharomyces cerevisiae. Genetics iyae022, https://doi.org/10.1093/genetics/iyae022
Chigweshe, L., A.J. MacQueen, and S.G. Holmes, 2022. Histone variant H2A.Z promotes meiotic chromosome axis organization in Saccharomyces cerevisiae. Genes, Genomes, and Genetics (G3) Volume 12, Issue 8, August 2022, jkac128. https://academic.oup.com/g3journal/article/12/8/jkac128/6591205
Holmes S. G., 2017 Nucleolar structure: Yeast rDNA feels the heat. Cell Cycle 16: 1485–1486. https://www.tandfonline.com/doi/pdf/10.1080/15384101.2017.1345234
Ringel, A.E., R. Ryznar, H. Picariello, K-L. Huang, A. G. Lazarus, and S. G. Holmes, 2013. Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase) is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination. PLOS Genetics 9 (10): e1003871. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003871
Sharma, U., D. Stefanova, and S. G. Holmes, 2013. Histone variant H2A.Z regulates sister chromatid cohesion in Saccharomyces cerevisiae. Molecular and Cellular Biology 33: 3473-3481. http://mcb.asm.org/content/33/17/3473.long
Motwani, T., M. Poddar, and S.G. Holmes, 2012. Sir3 and Epigenetic Inheritance of Silent Chromatin in Saccharomyces cerevisiae. Molecular and Cellular Biology 32: 2784-2793. http://mcb.asm.org/content/32/14/2784.long
Lazarus, A.G. and S. G. Holmes, 2011. A cis-acting tRNA gene imposes the cell cycle progression requirement for establishing silencing at the HMR locus in yeast. Genetics 187: 425-439. http://www.genetics.org/content/187/2/425.long
Martins-Taylor, K., U. Sharma, T. Rozario, and S. G. Holmes, 2011. H2A.Z (Htz1) controls the cell-cycle dependent establishment of transcriptional silencing at yeast telomeres. Genetics 187:89-104. http://www.genetics.org/content/187/1/89.long
Motwani, T., R. Doris, S. G. Holmes, and M. R. Flory, 2010. Ccq1p and the Condensin Proteins Cut3p and Cut14p Prevent Telomere Entanglements in the Fission Yeast Schizosaccharomyces pombe. Eukaryotic Cell 9:1612-1621. http://ec.asm.org/content/9/10/1612.long
Hickman, M., K. McCullough, A. Woike, L. Raducha-Grace, T. Rozario, M. L. Dula, E. Anderson, D. Margalit, and S. G. Holmes, 2007. Isolation and characterization of conditional alleles of the yeast SIR2 gene. Journal of Molecular Biology 367:1246-1257. http://www.sciencedirect.com/science/article/pii/S0022283607000848
Matecic, M., K. Martins-Taylor, M. Hickman, J. Tanny, D. Moazed, and S. G. Holmes, 2006. New alleles of SIR2 define cell cycle specific silencing functions. Genetics 173:1939-1950. http://www.genetics.org/content/173/4/1939.long
Martins-Taylor, K., M.L. Dula, and S.G. Holmes, 2004. Heterochromatin spreading at yeast telomeres occurs in M-phase. Genetics 168: 65-75. http://www.genetics.org/content/168/1/65.long
Papacs, L.A., Y. Sun, E. Anderson, J. Sun, and S. G. Holmes, 2004. REP3-mediated silencing in Saccharomyces cerevisiae. Genetics 166: 79-87. http://www.genetics.org/content/166/1/79.long
Matecic, M., S. Stuart, and S.G. Holmes, 2002. SIR2-induced inviability is suppressed by histone H4 overexpression. Genetics 162: 973-976. http://www.genetics.org/content/162/2/973.long
Holmes, S.G. and M.M. Smith, 2001. Replication of minichromosomes in Saccharomyces cerevisiae is sensitive to histone gene copy number and strain ploidy. Yeast. 18: 291-300. http://onlinelibrary.wiley.com/doi/10.1002/1097-0061(20010315)18:4%3C291::AID-YEA668%3E3.0.CO;2-V/full
Dula, M.L. and S.G. Holmes, 2000. Mga2p and Spt23p are modifiers of transcriptional silencing in yeast. Genetics 156: 933-941. http://www.genetics.org/content/156/3/933.long
Assay for chromosome cohesion
Sharma et al, Molecular and Cellular Biology 33: 3473-3481